Wednesday, December 21, 2011

The Benefits of L-Arginine For Diabetics

The main causes of mortality and morbidity in diabetics is Cardiovascular Disease. In recent years it is known that diabetes can affect the heart muscle is independently other than through the involvement of early atherosclerotic coronary arteries that cause ischemic heart disease. This is presumably due to changes such as the occurrence of interstitial fibrosis, the formation of collagen and hypertrophy of cardiac muscle cells. For decades, has been shown that nitric oxide is not only a role in the control of vasomotor tone but also play a role in the homeostasis of blood vessels and nerves as well as immunologic processes. Endogenous nitric oxide is produced through changes in the amino acid L-arginine to L-citrulline by the enzyme NO-synthase (NOS). L-arginine is the substrate for*the formation of NOS, so it is assumed that L-arginine supplementation may activate NOS and increase NO production and improve vasodilation. 

Amino acid L-arginine is one type of non-essential amino acids, amino acids that is very important for the formation of body proteins, but when the body lacks the body will synthesize the amount needed. The l-arginine benefits is proved able to induce dilation of blood vessels in the kidneys, the physiology of the results of studies that have been done previously that the amino acid l-arginine is a physiological precursor to NO (nitric oxide), which has to do with the effects of vasodilation and inhibition of platelet aggregation through increased formation of cyclic GMP. NO itself is a substance that is synthesized by vascular endothelial cells including blood vessels in the kidneys.


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